DNAH2 Antibody (N-term) [AMM08617G]

DNAH2 Antibody (N-term) [AMM08617G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DNAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the N-terminal region of human DNAH2.

Cellular Localisation: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme

Molecular Weight: 507698

Clone: Polyclonal

Gene Name: DNAH2 (HGNC:2948)

Gene ID: 146754

Function: As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583) . Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583) . Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583) .

Summary: Tissue Location: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung Expressed in spermatozoa (at protein level) (PubMed:31178125)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503