DNASE1 Antibody (Center) [APR07606G]

DNASE1 Antibody (Center) [APR07606G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DNASE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 87-121 amino acids from the Central region of human DNASE1.

Cellular Localisation: Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope

Molecular Weight: 31434

Clone: Polyclonal

Gene Name: DNASE1 (HGNC:2956)

Gene ID: 1773

Function: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032) . Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity) . Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278) . Binds specifically to G-actin and blocks actin polymerization (By similarity) . Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity) . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity) . Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity) .

Summary: Tissue Location: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: IHC-P-Leica, WB

Dilution: IHC-P-Leica--1:500 WB--1:1000

Synonyms: Deoxyribonuclease-1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI