DNM1L Antibody | 7603

DNM1L Antibody | 7603 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: Predicted species reactivity based on immunogen sequence: Rat: (100%) , Bovine: (100%)

Immunogen: DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L.
The immunogen is located within amino acids 530 - 580 of DNM1L.

Research Area: Apoptosis

Tested Application: E, WB, ICC, IF

Application: DNM1L antibody can be used for detection of DNM1L by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist; this antibody will detect the two longest isoforms.

Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate

Positive Control 2: Cat. No. 17-001 - HeLa Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 81 kDa
Observed: 80 kDa

Validation: N/A

Isoform: N/A

Purification: DNM1L antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: DNM1L antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: DNM1L antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: DNM1L Antibody: DLP1, DRP1, DVLP, EMPF, DYMPLE, HDYNIV, DLP1, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1) . DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2) . Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3) .