DNM2 Antibody (N-Term) [APR11778G]

DNM2 Antibody (N-Term) [APR11778G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DNM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 213-247 amino acids from human DNM2.

Cellular Localisation: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:P39052}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P39052}. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Midbody. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:P39054}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P39054}; Peripheral membrane protein {ECO:0000250|UniProtKB:P39054}. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity) Microtubule-associated. Also found in the postsynaptic density of neuronal cells. Co-localizes with PIK3C3 and RAB5A to the nascent phagosome (By similarity) . {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054}

Molecular Weight: 98064

Clone: Polyclonal

Gene Name: DNM2

Gene ID: 1785

Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity) . Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed:33713620) . Involved in cytokinesis (PubMed:12498685) . Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity) .

Summary: Tissue Location: Ubiquitously expressed.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC, IF

Dilution: IF--1:25 FC--1:25 WB--1:2000

Synonyms: Dynamin-2, 3.6.5.5, DNM2, DYN2