DNMT1 Polyclonal Antibody | E-AB-60994

DNMT1 Polyclonal Antibody | E-AB-60994 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNMT1

Application: WB, IF

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human DNMT1 (NP_001370.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 144 kDa/183 kDa/184 kDa

Molecular Weight(Observed): 200 kDa