DNMT3A Antibody (Center) [APR32975G]

DNMT3A Antibody (Center) [APR32975G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DNMT3A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the Central region of human DNMT3A.

Cellular Localisation: Nucleus. Chromosome Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin {ECO:0000250|UniProtKB:O88508}

Molecular Weight: 101858

Clone: Polyclonal

Gene Name: DNMT3A

Gene ID: 1788

Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:12138111, PubMed:16357870, PubMed:30478443) . DNA methylation is coordinated with methylation of histones (PubMed:12138111, PubMed:16357870, PubMed:30478443) . It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:12138111, PubMed:16357870, PubMed:30478443) . May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity) . Plays a role in paternal and maternal imprinting (By similarity) . Required for methylation of most imprinted loci in germ cells (By similarity) . Acts as a transcriptional corepressor for ZBTB18 (By similarity) . Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity) . Can actively repress transcription through the recruitment of HDAC activity (By similarity) . Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity) .

Summary: Tissue Location: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: DNA (cytosine-5) -methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A