DNMT3B Polyclonal Antibody | E-AB-65796

DNMT3B Polyclonal Antibody | E-AB-65796 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: DNMT3B, ICF, ICF1, M.HsaIIIB

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human DNMT3B (NP_008823.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:200-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 77-95 kDa

Molecular Weight(Observed): 95 kDa