DOCK2 Antibody (C-term) [APR15796G]

DOCK2 Antibody (C-term) [APR15796G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DOCK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1812-1846 amino acids from the C-terminal region of human DOCK2.

Cellular Localisation: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin

Molecular Weight: 211948

Clone: Polyclonal

Gene Name: DOCK2

Gene ID: 1794

Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.

Summary: Tissue Location: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Dedicator of cytokinesis protein 2, DOCK2, KIAA0209