Dofetilide | B1189

Dofetilide is a class III antiarrhythmic agent and inhibits the rapid delayed rectifier K⁺current (IKr) with IC₅₀values of 31.5 nM in guinea pig cardiomyocytes. At higher doses it demonstrates pro-arrhythmic activity in cell models. Therefore, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm and in the maintenance of sinus rhythm after conversion.

Dofetilide is a class III antiarrhythmic agent and inhibits the rapid delayed rectifier K⁺current (IKr) with IC₅₀values of 31.5 nM in guinea pig cardiomyocytes. At higher doses it demonstrates pro-arrhythmic activity in cell models. Therefore, dofetilide has been cautiously used in the treatment of atrial fibrillation, the conversion of flutter to sinus rhythm and in the maintenance of sinus rhythm after conversion.

B1189 | Dofetilide DataSheet

Alternate Name/Synonyms: 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Appearance: White Solid

Formulation: N/A

CAS Number: 115256-11-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₇N₃O₅S₂

Molecular Weight: 441.56

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A class III antiarrhythmic agent

MDL Number: MFCD00869707

PubChem CID: 71329

SMILES: CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C

InChi: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3

InChi Key: IXTMWRCNAAVVAI-UHFFFAOYSA-N