DOK4 Polyclonal Antibody | E-AB-10910

DOK4 Polyclonal Antibody | E-AB-10910 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: docking protein 4, Downstream of tyrosine kinase 4, FLJ10488, insulin receptor substrate 5, IRS5

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Neuroscience, Signal Transduction

Background: Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.

Concentration: 0.5 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human DOK4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A