Donepezil Hydrochloride | B3092

Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.

Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.

B3092 | Donepezil Hydrochloride DataSheet

Alternate Name/Synonyms: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride; Aricept; 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride; E2020

Appearance: White to off-white powder

Formulation:

CAS Number: 120011-70-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₂₄H₃₀ClNO₃

Molecular Weight: 415.95

Cell-Permeable?: True

Purity: ≥ 97%

Solubilities: ~4 mg/ml in ethanol, ~20 mg/ml in water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent acetylcholinesterase inhibitor

MDL Number: MFCD00881312

PubChem CID: 5741

SMILES: COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl

InChi: InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

InChi Key: XWAIAVWHZJNZQQ-UHFFFAOYSA-N