Doramapimod | 1954

Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.

Doramapimod is a potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.

1954 | Doramapimod DataSheet

Alternate Name/Synonyms: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 285983-48-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₃₇N₅O₃

Molecular Weight: 527.66

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent p38 MAP kinase inhibitor

MDL Number: MFCD09752957

PubChem CID: 156422

SMILES: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

InChi: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2, 3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19- 16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChi Key: MVCOAUNKQVWQHZ-UHFFFAOYSA-N