Dorsmorphin dihydrochloride | 2835

A water-soluble derivative of the potent, reversible, AMPK inhibitor Dorsomorphin (Cat. No.1686).

Dorsomorphin dihydrochloride is a potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKCθ, SYK and ZAPK.

2835 | Dorsmorphin dihydrochloride DataSheet

Alternate Name/Synonyms: Compound C, BML-275; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1219168-18-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₅N₅O.2HCl

Molecular Weight: 472.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H2O (> 40 mg/ml) or DMSO (>5 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent AMPK inhibitor

MDL Number: MFCD11112197

PubChem CID: 49761481

SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

InChi: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H

InChi Key: RJDVIJJQKMGPMV-UHFFFAOYSA-N