DPP IV Inhibitor, NVP DPP 728 | 1964

A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC₅₀ = 14 nM). Displays >15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.

DPP IV Inhibitor, NVP DPP 728 is a potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC₅₀ = 14 nM). Displays >15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.

1964 | DPP IV Inhibitor, NVP DPP 728 DataSheet

Alternate Name/Synonyms: 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 247016-69-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₈N₆O.2HCl

Molecular Weight: 371.27

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mM) or EtOH (~ 100 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent DPP IV Inhibitor,

MDL Number: N/A

PubChem CID: 9799555

SMILES: C1CC(N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N.Cl.Cl

InChi: InChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21- 7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19, 20);2*1H/t13-;;/m0../s1

InChi Key: VNACOBVZDCLAEV-GXKRWWSZSA-N