DPP8 Antibody (C-term) [APR05757G]

DPP8 Antibody (C-term) [APR05757G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DPP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-876 amino acids from the C-terminal region of human DPP8.

Cellular Localisation: Cytoplasm

Molecular Weight: 103358

Clone: Polyclonal

Gene Name: DPP8 {ECO:0000303|PubMed:11012666, ECO:0000312|HGNC:HGNC:16490}

Gene ID: 54878

Function: Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396) (Probable) . Acts as an inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis: inhibits pyroptosis by preventing activation of NLRP1 and CARD8 via an unknown mechanism (PubMed:27820798, PubMed:29967349, PubMed:32796818) .

Summary: Tissue Location: Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Dipeptidyl peptidase 8, DP8, Dipeptidyl peptidase IV-related protein 1, DPRP-1, Dipeptidyl peptidase VIII, DPP VIII, Prolyl dipeptidase DPP8, DPP8, DPRP1