DR4 Antibody | 3061R

Apoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family thro?gh their death domain (DD) containing receptors, TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4 (death receptor 4) and TRAIL-R1. The ligand for this novel death receptor has been identified and termed TRAIL. DR4 is expressed in most of the human tissues including spleen, peripheral blood leukocytes (PBLs), small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NFkB activation in many tissues and cells.

3061R | DR4 Antibody DataSheet

Antibody Target: DR4

Target Alternative Name: TNFRSF10A, TRAILR1, mgC9365, APO2, CD261, TRAIL-R1, TRAILR-1

Tag Line:

Category: DR4

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human

Immunogen Sequence: Synthetic peptide corresponding to residues surrounding amino acids 454 of human DR4

Accession #: O00220

Gene ID: 8797

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit anti-DR4 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application: Western blot

Positive Control:

Application And Usages: Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects a 57 kDa in samples from human origin. Jurkat cell lysate can be used as a positive control.

Country of Animal Origin: China

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified: Not Verified

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified