Droxinostat | 9570

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 with IC₅₀ values of 16.9, 2.47 and 1.46 μM, respectively. Droxinostat sensitizes cells to apoptosis by decreasing c-FLIPL and c-FLIPS expression, reducing cell survival, and inducing apoptosis.

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 with IC₅₀ values of 16.9, 2.47 and 1.46 μM, respectively. Droxinostat sensitizes cells to apoptosis by decreasing c-FLIPL and c-FLIPS expression, reducing cell survival, and inducing apoptosis.

9570 | Droxinostat DataSheet

Alternate Name/Synonyms: 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 99873-43-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₁₄ClNO₃

Molecular Weight: 243.69

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective inhibitor of HDAC3, HDAC6, and HDAC8

MDL Number: MFCD01326592

PubChem CID: 568416

SMILES: CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO

InChi: InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)

InChi Key: JHSXDAWGLCZYSM-UHFFFAOYSA-N