DSG1 polyclonal Antibody | BS71331

DSG1 polyclonal Antibody | BS71331 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100

Background: Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DSG1 polyclonal Antibody detects endogenous levels of DSG1 protein.

Molecular Weight: ~ 150 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Desmoglein-1; Desmoglein 1; Desmoglein1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; DSG1; CDHF4

Immunogen: Recombinant protein of human DSG1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: