DSP Polyclonal Antibody | E-AB-12373

DSP Polyclonal Antibody | E-AB-12373 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 250/210 kDa paraneoplastic pemphigus antigen, DCWHKTA, Desmoplakin (DPI DPII), Desmoplakin, Desmoplakin I, Desmoplakin II, DESP, DP, DP I, DP II, DPI, DPII, DSP, KPPS2, PPKS 2, PPKS2

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Signal Transduction

Background: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

Concentration: 0.5 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human DSP

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A