DUS2L polyclonal Antibody | BS61523

DUS2L polyclonal Antibody | BS61523 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: DUS2L (tRNA-dihydrouridine synthase 2-like), also known as URLC8 (upregulated in lung cancer protein 8) or SMM1, is a 493 amino acid member of the DUS protein family. Localized to cytoplasm and endoplasmic reticulum, DUS2L uses FAD as a cofactor to catalyze the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. DUS2L contains one DRBM (double-stranded RNA-binding) domain and has been found to interact with ProRS. DUS2L is upregulated in most lung cancer cells and has weak expression in normal heart, skeletal muscle and placenta. The gene that encodes DUS2L maps to human chromosome 16q22.1 and murine chromosome 8 D3.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DUS2L polyclonal Antibody detects endogenous levels of DUS2L protein.

Molecular Weight: ~ 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: tRNA-dihydrouridine (20) synthase [NAD (P) +]-like; Dihydrouridine synthase 2; Up-regulated in lung cancer protein 8; URLC8; tRNA-dihydrouridine synthase 2-like; hDUS2

Immunogen: Synthetic peptide, corresponding to amino acids 441-485 of Human DUS2L.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: