DUSP6 Antibody| F45736-0.08ML/F45736-0.4ML/R35156-100UG

DUSP6 Antibody| F45736-0.08ML/F45736-0.4ML/R35156-100UG | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Bovine

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the DUSP6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This DUSP6 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 59-88 from the human protein was used as the immunogen for this DUSP6 antibody.

Storage: Aliquot the DUSP6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A