Dynasore | 1900

Cell-permeable. A reversible, noncompetitive inhibitor of dynamin that interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition.

Dynasore is a reversible, noncompetitive inhibitor of dynamin that interferes in vitro with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition.

1900 | Dynasore DataSheet

Alternate Name/Synonyms: 3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 304448-55-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₄N₂O₄ . H₂O

Molecular Weight: 322.31 .18.0

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (10 mg/ml) or EtOH (1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent dynamin inhibitor

MDL Number: MFCD11045288

PubChem CID: 5717066

SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NNC=C3C=CC(=O)C(=C3)O)O

InChi: InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,19,22-23H,(H,20,24)/b11-10+

InChi Key: NRQJUIHYFNUXFT-ZHACJKMWSA-N