E-64 | 1739

E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. A very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition and displays low toxicity.

E-64 is an irreversible, cell-permeable, potent, and highly selective cysteine protease inhibitor. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain.

1739 | E-64 DataSheet

Alternate Name/Synonyms: trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide

Appearance: White crystalline solid

Formulation: N/A

CAS Number: 66701-25-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₇N₅O₅

Molecular Weight: 357.41

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (25 mg/ml) or H₂O (20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A cysteine protease inhibitor

MDL Number: MFCD00080261

PubChem CID: 439487

SMILES: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O

InChi: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10+,11+/m0/s1

InChi Key: LTLYEAJONXGNFG-HBNTYKKESA-N