E-7046 | B1966

E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.

E-7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4 (IC₅₀ = 13.5 nM). It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.

B1966 | E-7046 DataSheet

Alternate Name/Synonyms: 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1369489-71-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈F₅N₃O₄

Molecular Weight: 483.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A specific type 4 prostaglandin E2 (PGE2) receptor EP4 atagonist

MDL Number: N/A

PubChem CID: 56944705

SMILES: CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(N(N=C2C(F)F)C)OC3=CC=CC(=C3)C(F)(F)F

InChi: InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1

InChi Key: MKLKAQMPKHNQPR-NSHDSACASA-N