E Cadherin Antibody (CDH1)| F44156-0.08ML

E Cadherin Antibody (CDH1)| F44156-0.08ML | Gentaur UK, US & Europe Distribution

Background: CDH1 is a classical cadherin from the cadherin superfamily. This protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, FACS, ELISA

Application Details: Western blot: 1:1000, Flow Cytometry: 1:10-1:50

Application Note: Titration of the E Cadherin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This E Cadherin antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 160-189 from the human protein was used as the immunogen for this E Cadherin antibody.

Storage: Aliquot the E Cadherin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A