EAI-045 | B1274

EAI-045 is a potent and selective EGFR inhibitor. EAI-045 targets selected drug-resistant EGFR mutants but spares the wild-type receptor. EAI-045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays.

EAI-045 is a potent and selective EGFR inhibitor. EAI-045 targets selected drug-resistant EGFR mutants but spares the wild-type receptor. EAI-045 inhibits L858R/T790M-mutant EGFR with low-nanomolar potency in biochemical assays.

B1274 | EAI-045 DataSheet

Alternate Name/Synonyms: 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1942114-09-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄FN₃O₃S

Molecular Weight: 383.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective EGFR inhibitor.

MDL Number: N/A

PubChem CID: 121231412

SMILES: C1C2=CC=CC=C2C(=O)N1C(C3=C(C=CC(=C3)F)O)C(=O)NC4=NC=CS4

InChi: InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

InChi Key: YTUFHOKUFOQRDF-UHFFFAOYSA-N