EBI-2511 | B2433

EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC₅₀ of 4 nM for EZH2(A667G). EBI-2511 displays excellent in vivo efficacy in Pfeiffer tumor Xenograft models in mouse and could be useful for the treatment of cancers associated with EZH2 mutations.

EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC₅₀ of 4 nM for EZH2(A667G). EBI-2511 displays excellent in vivo efficacy in Pfeiffer tumor Xenograft models in mouse and could be useful for the treatment of cancers associated with EZH2 mutations.

B2433 | EBI-2511 DataSheet

Alternate Name/Synonyms: EBI2511, N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl-(tetrahydro-2H-pyran-4-yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 2098546-05-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₄₈N₄O₄

Molecular Weight: 576.77

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective EZH2 Inhibitor

MDL Number:

PubChem CID: 133081962

SMILES: CCC1=C(C2=C(C=C1N(CC)C3CCOCC3)OC(=C2)C4CCN(CC4)C(C)C)C(=O)NCC5=C(C=C(NC5=O)C)C

InChi: InChI=1S/C34H48N4O4/c1-7-26-29(38(8-2)25-11-15-41-16-12-25)19-31-27(18-30(42-31)24-9-13-37(14-10-24)21(3)4)32(26)34(40)35-20-28-22(5)17-23(6)36-33(28)39/h17-19,21,24-25H,7-16,20H2,1-6H3,(H,35,40)(H,36,39)

InChi Key: NYWVSLBALKNFJR-UHFFFAOYSA-N