Ebselen | 2169

An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC₅₀ of 5.17 µM.

Ebselen is a glutathione peroxidase (GPx) mimetic and a peroxynitrite scavenger. Acts as an antioxidant and anti-inflammatory agent. Also inhibits Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC₅₀ of 5.17 µM.

2169 | Ebselen DataSheet

Alternate Name/Synonyms: 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 60940-34-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₉NOSe

Molecular Weight: 274.18

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A glutathione peroxidase (GPx) mimetic and a peroxynitrite scavenger

MDL Number: MFCD00210937

PubChem CID: 3194

SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2

InChi: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

InChi Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N