EDARADD Polyclonal Antibody | E-AB-52310

EDARADD Polyclonal Antibody | E-AB-52310 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Cr, Crinkled homolog, ectodysplasia A receptor associated death domain, Ectodysplasin-A receptor-associated adapter protein, ED3, EDA3, EDAD, EDAR associated death domain, EDAR-associated death domain protein, EDARADD, Protein crinkled homolog

Application: IHC, ELISA

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction

Background: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Concentration: 0.9 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Full length fusion protein

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:35-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A