EED (1- 441aa), Human recombinant | 7667

Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.

7667 | EED 1- 441aa Human recombinant DataSheet

Biomolecule/Target: EED

Synonyms: EED (1- 441aa), Human recombinant

Alternates names: Embryonic Ectoderm Development

Taglines: Repressor of gene activity through histone deacetylation

NCBI Gene ID #: 6356

NCBI Gene Symbol: CCL-11

Gene Source: Human

Accession #: P51671

Recombinant: Yes

Source: Insect (SF21) cells (baculovirus expression system)

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 53.5 kDa (1- 441 aa + NT His Tag)

Concentration: N/A

Appearance: Liquid

Physical form description: 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: N/A