EED-226 | B1845

EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model.

EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model.

B1845 | EED-226 DataSheet

Alternate Name/Synonyms: N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 2083627-02-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₅N₅O₃S

Molecular Weight: 369.4

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor

MDL Number: N/A

PubChem CID: 123132228

SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4

InChi: InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

InChi Key: DYIRSNMPIZZNBK-UHFFFAOYSA-N