EHop-016 | 9595

EHop-016 is an analog of NSC-23766 (Cat. No. 1941) that acts as a potent inhibitor of Rac GTPase (IC₅₀ = 1.1 µM for Rac1). The IC₅₀ of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than for NSC-23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42.

EHop-016 is an analog of NSC-23766 (Cat. No. 1941) that acts as a potent inhibitor of Rac GTPase (IC₅₀ = 1.1 µM for Rac1). The IC₅₀ of 1.1 μM for Rac inhibition by EHop-016 is ∼100-fold lower than for NSC-23766. EHop-016 is specific for Rac1 and Rac3 at concentrations of ≤5 μM. At higher concentrations, EHop-016 inhibits the close homolog Cdc42.

9595 | EHop-016 DataSheet

Alternate Name/Synonyms: 4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 1380432-32-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₀N₆O

Molecular Weight: 430.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Rac GTPase

MDL Number: N/A

PubChem CID: 51031035

SMILES: CCN1C2=C(C=C(C=C2)NC3=NC(=NC=C3)NCCCN4CCOCC4)C5=CC=CC=C51

InChi: InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29)

InChi Key: AFTZZRFCMOAFCR-UHFFFAOYSA-N