EIF2S3L Antibody (Center) [APR31741G]

EIF2S3L Antibody (Center) [APR31741G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This EIF2S3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-299 amino acids from the Central region of human EIF2S3L.

Cellular Localisation: N/A

Molecular Weight: 51229

Clone: Polyclonal

Gene Name: EIF2S3B (HGNC:43863)

Gene ID: N/A

Function: As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF- 5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B (By similarity) . Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity) .

Summary: Tissue Location: Specifically expressed in testis at the mRNA level.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Putative eukaryotic translation initiation factor 2 subunit 3-like protein, Eukaryotic translation initiation factor 2 subunit gamma A, eIF-2-gamma A, eIF-2gA, EIF2S3L