Elastase Inhibitor | 1922

A potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone.

Elastase inhibitor is a potent, irreversible inhibitor of human neutrophil elastase (HNE). The structure of the enzyme-inhibitor complex reveals crosslinking of the catalytic residues His-57 and Ser-195 by the peptidyl chloromethylketone.

1922 | Elastase Inhibitor DataSheet

Alternate Name/Synonyms: MeOSuc-Ala-Ala-Pro-Ala-chloromethylketone; MeOSuc-AAPA-CMK

Appearance: White solid

Formulation: N/A

CAS Number: 111682-13-4

Structure Available?: Yes

Peptide sequence: Yes

Salt Form: No

Molecular Formula: C₂₀H₃₁ClN₄O₇

Molecular Weight: 474.94

Cell-Permeable?: No

Purity: ≥98% by TLC

Solubilities: DMSO

Handling: Protect from air and mositure

Country of Origin: USA

Tag Line: A potent, irreversible human leukocyte elastase (HLE) inhibitor

MDL Number: MFCD00238296

PubChem CID: 5748191

SMILES: CC(C(=O)NC(C)C(=O)NC(=O)C1CCCN1C(C)C(=O)CCl)NC(=O)CCC(=O)OC

InChi: InChI=1S/C20H31ClN4O7/c1-11(22-16(27)7-8-17(28)32-4)18(29)23-12(2)19(30) 24-20(31)14-6-5-9-25(14)13(3)15(26)10-21/h11-14H,5-10H2,1-4H3,(H,22, 27)(H,23,29)(H,24,30,31)/t11-,12-,13-,14-/m0/s1

InChi Key: RHGXHACEVXSAHV-XUXIUFHCSA-N