Elvitegravir | 9465

Elvitegravir is a novel HIV-1 integrase inhibitor that blocks strand transfer by the viral enzyme. It displays an IC₅₀ of 7.2 nM in the strand transfer assay, and shows an EC₅₀ of 0.9 nM in an acute HIV-1 infection assay.

Elvitegravir is a novel HIV-1 integrase inhibitor that blocks strand transfer by the viral enzyme. It displays an IC₅₀ of 7.2 nM in the strand transfer assay, and shows an EC₅₀ of 0.9 nM in an acute HIV-1 infection assay.

9465 | Elvitegravir DataSheet

Alternate Name/Synonyms: 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; EVG, JTK-303/GS-9137

Appearance: White solid

Formulation: N/A

CAS Number: 697761-98-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₃ClFNO₅

Molecular Weight: 447.88

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A HIV-1 integrase inhibitor

MDL Number: N/A

PubChem CID: 5277135

SMILES: CC(C)C(CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O

InChi: InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1

InChi Key: JUZYLCPPVHEVSV-LJQANCHMSA-N