Emetine dihydrochloride | 1970

A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.

Emetine dihydrochloride is a bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.

1970 | Emetine dihydrochloride DataSheet

Alternate Name/Synonyms: 2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 316-42-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₄₀N₂O₄·2HCl

Molecular Weight: 553.56

Cell-Permeable?: No

Purity: ≥98% by titration

Solubilities: Water (~ 100 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A protein synthesis inhibitor

MDL Number: MFCD00135589

PubChem CID: 3068143

SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl.Cl

InChi: InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

InChi Key: JROGBPMEKVAPEH-GXGBFOEMSA-N