EMR4 (I140) polyclonal Antibody | BS2792

EMR4 (I140) polyclonal Antibody | BS2792 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: FIRE is a 689 amino acid protein that maps to human gene EMR4. FIRE is also known as EGF-like module-containing mucin-like hormone receptor-like 4 and is a member of the the G protein-coupled receptor 2 family, LN-TM7 subfamily. The epidermal growth factor-transmembrane seven (EGF-TM7) family are proteins that express EGF-like domains at their extracellular N-terminus coupled to a classical seven-transmembrane (TM7) cassette. FIRE is believed to mediate the cellular interaction between myeloid cells and β cells. FIRE is a membrane bound, multi-pass protein that is proteolytically cleaved into two subunits, an extracellular α subunit and a seven-transmembrane subunit. FIRE contains one GPS (G protein-coupled receptor proteolytic cleavage site) domain and two EGF (epidermal growth factor) -like domains, the second of which mediates the interaction with the putative ligand.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: EMR4 (I140) polyclonal Antibody detects endogenous levels of EMR4 protein.

Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Putative EGF-like module-containing mucin-like hormone receptor-like 4; EGF-like module receptor 4; G-protein coupled receptor 127; G-protein coupled receptor PGR16; EMR4; GPR127; PGR16; EMR4P; FIRE

Immunogen: Synthetic peptide, corresponding to amino acids 108-164 of Human EMR4.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A