Endoglin, murine recombinant | 4531

Endoglin is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Endoglin has been found to be part of the TGF-beta1 receptor complex and may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development . CD105 Mouse Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, polypeptide containing 581 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 75-85 kDa under reducing conditions in SDS-PAGE. Based on N-terminal sequence analysis, the primary structure of recombinant mature Endoglin starts at Glu 26. The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques.

4531 | Endoglin murine recombinant DataSheet

Biomolecule/Target: Endoglin

Synonyms: CD105, ENG, END, ORW, HHT1, ORW1, FLJ41744, Endoglin

Alternates names: Adipose differentiation-related protein, ADRP, ADFP, MGC10598, Perilipin-2

Taglines: A part of the TGF beta receptor complex

NCBI Gene ID #: 123

NCBI Gene Symbol: PLIN2

Gene Source: Mouse

Accession #: Q99541

Recombinant: Yes

Source: Sf9 cells

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: 95%

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 49.0 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from sterile solution without additives

Reconstitution Instructions: Add de-ionized HO to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Amino acid sequence: N/A