ENMD-2076 | B1938

ENMD-2076 is a selective inhibitor of Aurora A and Flt3 with IC₅₀ values of 14 and 1.86 nM, respectively. Displays 5-fold selectivity for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.

ENMD-2076 is a selective inhibitor of Aurora A and Flt3 with IC₅₀ values of 14 and 1.86 nM, respectively. Displays 5-fold selectivity for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα.

B1938 | ENMD-2076 DataSheet

Alternate Name/Synonyms: 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 934353-76-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₅N₇

Molecular Weight: 375.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 18 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective inhibitor of Aurora A and Flt3

MDL Number: N/A

PubChem CID: 16041424

SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)C=CC4=CC=CC=C4

InChi: InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+

InChi Key: BLQYVHBZHAISJM-CMDGGOBGSA-N