Epalrestat | 2397

Epalrestat is an aldose reductase inhibitor (IC₅₀ = 10 nM (rat lens) and 25 nM (human placenta). It reduces sorbitol accumulation in the sciatic nerve, erythrocytes and ocular tissue. May be used to prevent or slow the progression of diabetic neuropathy.

Epalrestat is an aldose reductase inhibitor (IC₅₀ = 10 nM (rat lens) and 25 nM (human placenta).

2397 | Epalrestat DataSheet

Alternate Name/Synonyms: 2-[(5Z)-5-[(E)-3-phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid

Appearance: Yellow solid

Formulation: N/A

CAS Number: 82159-09-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₃NO₃S₂

Molecular Weight: 319.4

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: An aldose reductase inhibitor

MDL Number: N/A

PubChem CID: 1549120

SMILES: CC(=CC1=CC=CC=C1)C=C2C(=O)N(C(=S)S2)CC(=O)O

InChi: InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-

InChi Key: CHNUOJQWGUIOLD-NFZZJPOKSA-N