Epothilone B | 2012

A macrolide anticancer agent. Similar to paclitaxel (Cat. No. 1567-25), epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Also induces G2-M cell cycle arrest (EC₅₀= 3 - 92 nM).

Epothilone B is a macrolide anticancer agent. Similar to paclitaxel (Cat. No. 1567-25), epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Also induces G2-M cell cycle arrest (EC₅₀= 3 - 92 nM).

2012 | Epothilone B DataSheet

Alternate Name/Synonyms: EPO-906; EpoB; Patupilone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 152044-54-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₄₁NO₆S

Molecular Weight: 507.68

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (40 mg/ml) or EtOH (40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A microtubule depolymerization inhibitor and an anticancer agent

MDL Number: MFCD02101921

PubChem CID: 448013

SMILES: CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C

InChi: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18 (4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17, 20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-, 27+/m0/s1

InChi Key: QXRSDHAAWVKZLJ-PVYNADRNSA-N