EPZ-015666 | 9410

EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.

EPZ015666 is a potent, selective PRMT5 inhibitor (Ki of 5 nM); displays >20,000-fold selectivity over other PMTs. EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50, which is necessary for the formation of an active methyltransferase complex.

9410 | EPZ-015666 DataSheet

Alternate Name/Synonyms: N-​[(2S)-​3-​(3,​4-​dihydro-​2(1H)-​isoquinolinyl)-​2-​hydroxypropyl]-​6-​(3-​oxetanylamino)-​4-​pyrimidinecarboxamide; GSK3235025

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1616391-65-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₅N₅O₃

Molecular Weight: 383.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PRMT5 inhibitor

MDL Number: N/A

PubChem CID: 90241673

SMILES: C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O

InChi: InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1

InChi Key: ZKXZLIFRWWKZRY-KRWDZBQOSA-N