Description
A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.
EPZ004777 is a potent and selective DOT1L inhibitor.
Alternate Name/Synonyms: 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1338466-77-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₄₁N₇O₄
Molecular Weight: 539.67
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A potent DOT1L inhibitor
MDL Number: N/A
PubChem CID: 70702060
SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
InChi: InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
InChi Key: WXRGFPHDRFQODR-QQNJPBSNSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |