ER Beta/NR3A2 Protein, Human Recombinant | P1628

Estrogen receptor beta (ERβ) is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. ERβ is a potent tumor suppressor and plays a crucial role in many cancer types such as prostate cancer. Several lines of evidence suggest that the inhibitory effect of ERβ is due to blockade of cell cycle progression. ERβ knockdown results in a significant growth of several breast cancer cells. ERβ is also found to have anti proliferative effects in disease progression. ERβ can perform its role in tumor inhibition by regulating mitochondrial function and dynamics.

P1628 | ER Beta/NR3A2 Protein, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: ESRB,ESR-BETA,ER Beta,Estrogen receptor beta,ER-BETA,Estrogen receptor beta 4,NR3A2

Alternates names: ESRB,ESR-BETA,ER Beta,Estrogen receptor beta,ER-BETA,Estrogen receptor beta 4,NR3A2

Taglines:

NCBI Gene ID #: 2100

NCBI Gene Symbol: NP_001278641.1

Gene Source: Human

Accession #: Q92731-3, NP_001278641.1

Recombinant: TRUE

Source: E.coli

Purity by SDS-PAGE: ≥ 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: < 1 EU/ug of protein as determined by LAL method

Activity (Specifications/test method):

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 38 kDa

Concentration:

Appearance: Lyophilized powder

Physical form description:

Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.

Amino acid sequence: (Met1-Ala323)

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans