ERAP2 Antibody | 7469

ERAP2 Antibody | 7469 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Bovine: (75%)

Immunogen: ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2.
The immunogen is located within amino acids 110 - 160 of ERAP2 .

Research Area: Innate Immunity

Tested Application: E, WB

Application: ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificiy: ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.

Positive Control 1: Cat. No. 1316 - Human Ovary Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 106 kDa
Observed: 120kDa

Validation: N/A

Isoform: N/A

Purification: ERAP2 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: ERAP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: ERAP2 Antibody : LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2) , a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1, 2) . Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1) . Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3) .