ERG25 Antibody (C-term) [APR31180G]

ERG25 Antibody (C-term) [APR31180G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ERG25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-293 amino acids from the C-terminal region of human ERG25.

Cellular Localisation: Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 35216

Clone: Polyclonal

Gene Name: MSMO1

Gene ID: 6307

Function: Catalyzes the three-step monooxygenation required for the demethylation of 4, 4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol (PubMed:21285510, PubMed:28673550, PubMed:23583456, PubMed:26114596) . Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha, 25- dihydroxy-2beta- (3-hydroxypropoxy) -cholecalciferol), a second- generation vitamin D analog, into 1alpha, 2beta, 25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O- dehydroxypropylation (PubMed:26038696) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Methylsterol monooxygenase 1, C-4 methylsterol oxidase, MSMO1, DESP4, ERG25, SC4MOL