400

Erlotinib Hydrochloride, 10 mg

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SKU:
400-SIH-444-10MG-GEN
Availability:
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NULL360.00

Description

Erlotinib Hydrochloride, 10 mg

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Additional Information

Short Description:
EGFR Kinase inhibitor
Research Area:
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Alternative Name(s):
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Category:
Small Molecules
Product Type:
Inhibitor
CAS No.:
183319-69-9
Molecular Formula:
C22H24ClN3O4
Molecular Weight:
429,9
Source:
Synthetic
Purity:
≥99%
Solubility:
Soluble in DMSO at 18 mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubi
Appearance:
Solid powder
Storage:
-20ºC
Shipping:
Shipped Ambient
SMILES:
[H+].C1=C(OCCOC)C(=CC2=NC=NC(=C12)NC3=CC(=CC=C3)C#C)OCCOC.[Cl-]
InChI:
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChIKey:
GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Field of Use:
For in vitro research use only.
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Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines...
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