Erlotinib, Hydrochloride Salt | 1588

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM). Studies in cell lines and enzyme assays have both shown that erlotinib inhibits EGFR at concentrations significantly lower than those needed to inhibit c-src and v-abl.

Erlotinib is an inhibitor of human Epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 2 nM) and decreases EGFR autophosphorylation in tumor cells (IC₅₀ = 20 nM).

1588 | Erlotinib, Hydrochloride Salt DataSheet

Alternate Name/Synonyms: CP-358774, OSI-774

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 183319-69-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₃N₃O₄.HCl

Molecular Weight: 429.9

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An EGFR kinase inhibitor

MDL Number: MFCD07781272

PubChem CID: 176871

SMILES: COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

InChi: InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8- 26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3, (H,23,24,25);1H

InChi Key: GTTBEUCJPZQMDZ-UHFFFAOYSA-N