Ertugliflozin | B1896

Ertugliflozin is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2); increases the excretion of glucose with a 2,000-fold selectivity over SGLT1 (IC₅₀ = 0.877 and 1,960 nM, respectively, for human isoforms in vitro.

Ertugliflozin is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2); increases the excretion of glucose with a 2,000-fold selectivity over SGLT1 (IC₅₀ = 0.877 and 1,960 nM, respectively, for human isoforms in vitro.

B1896 | Ertugliflozin DataSheet

Alternate Name/Synonyms: (1S,2S,3S,4R,5S)-5-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-1-hydroxymethyl-6,8-dioxabicyclo(3.2.1)octane-2,3,4-triol; PF-04971729

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1210344-57-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅ClO₇

Molecular Weight: 436.89

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective sodium-dependent glucose cotransporter 2(SGLT2) inhibitor

MDL Number: N/A

PubChem CID: 44814423

SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl

InChi: InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1

InChi Key: MCIACXAZCBVDEE-CUUWFGFTSA-N