ESR2 Antibody (Center) (Ascites) [AMM04447G]

ESR2 Antibody (Center) (Ascites) [AMM04447G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This ESR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the Central region of human ESR2.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:19126643, ECO:0000269|PubMed:20074560}

Molecular Weight: 59216

Clone: Monoclonal

Gene Name: ESR2

Gene ID: 2100

Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen- dependent manner (PubMed:20074560) .

Summary: Tissue Location: [Isoform 1]: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. [Isoform 4]: Expressed in the testis. [Isoform 6]: Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.

Form: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:100~4000

Synonyms: Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2